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Histamine... the unseen instigator of unexplained symptoms

A common trait in chronic health conditions...

MCAS (Mast Cell Activation Syndrome) and histamine intolerance are two distinct medical conditions that are the result of an abnormal response to histamine.  Although both conditions share similar symptoms, the underlying mechanisms differ, and proper diagnosis and treatment are necessary.

MCAS occurs when mast cells, a type of immune cell, become overactive and release excessive amounts of histamine and other inflammatory substances in response to triggers that would not normally cause a reaction.  Histamine intolerance on the other hand is a condition in which the body has difficulty breaking down histamine.  You can experience histamine intolerance and MCAS in combination to each other or you can experience one or the other condition on their own.

MCAS and Histamine Intolerance

Symptoms vary and fluctuate - you many not experience them all:


Gastrointestinal:  Dumping syndrome, bloating, stomach pain/cramps, reflux, nausea, constipation diarrhoea

Cardiovascular:  Low blood pressure,  fast heart rate, fainting or light headedness, chest pain

Respiratory:  Wheezing, coughing, sore throat, shortness of breath, throat swelling

Urinary and genital:  Frequent urination, bladder urgency, pain during urination, genital pain, itching or swelling

Neurological:  Migraine, headaches,, brain fog, numbness, pain, tingling skin, anxiety, decline in mental health

Musculoskeletal:  Joint and muscle aches and pains, loss of bone mineral density

Oral and nasal:  Eye watering, nasal or sinus congestion, post nasal drip, itching, tingling lips and tongue

Skin:  Flushing/hot flushes, itching with or without  hives and welts

Allergies:  Anaphylaxis,  food and environmental allergies 

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